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Clindamycin is an antibiotic. It fights bacteria in the body. Tretinoin is a form of vitamin A. It reduces the amount of oil released by oil glands in your skin, and helps your skin renew itself more quickly. Clindamycin and tretinoin is a combination medicine used to treat severe nodular acne in adults and children who are at least 12 years old. Clindamycin and tretinoin topical may also be used for purposes other than those listed in this medication guide.
Although this medicine is applied to the skin, your body may absorb enough clindamycin to affect certain medical conditions you may have.
You should not use this medication if you are allergic to clindamycin or tretinoin, or if you have:
inflammation of your intestines (also called enteritis);
Crohn's disease, ulcerative colitis; or
if you have ever had severe diarrhea caused by antibiotic medicine.
You should not use clindamycin and tretinoin topical if you are also taking another antibiotic called erythromycin, or using other skin medications that contain erythromycin.
To make sure clindamycin and tretinoin topical is safe for you, tell your doctor if you have:
any allergies; or
a history of stomach or intestinal disorders.
FDA pregnancy category C. It is not known whether clindamycin and tretinoin topical will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.
It is not known whether clindamycin and tretinoin topical passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.
This medicine should not be used on a child younger than 12 years old.
Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended. Using more medicine or applying it more often than prescribed will not make it work any faster, and may increase side effects. Wash your hands before and after applying this medication. Wash your face with a mild soap or cleanser and pat the skin dry with a clean towel. Use only a pea-sized amount of clindamycin and tretinoin topical. Apply to your entire face every night at bedtime.
Do not wash your face more than 3 times daily while using this medication. Washing more often or scrubbing your face when you wash it can make your acne worse. Avoid getting this medication in your eyes, mouth, or nose (or in the creases of your nose), or on your lips. If it does get into any of these areas, wash with water. Do not apply this medicine to sunburned, windburned, dry, chapped, irritated, or broken skin.
Use this medication for the full prescribed length of time, even if you think it is not working. Call your doctor if skin irritation becomes severe or if your acne does not improve after several weeks of using this medicine. If you need surgery, tell the surgeon ahead of time that you are using clindamycin and tretinoin topical.
Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.
It is not likely that other drugs you take orally or inject will have an effect on topically applied clindamycin and tretinoin. But many drugs can interact with each other. Tell each of your health care providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products.
Avoid washing treated skin or applying other skin products for at least 1 hour after applying this medicine. Avoid using other medications on the areas you treat with clindamycin and tretinoin topical unless your doctor tells you to. Avoid using skin products that can cause irritation, such as harsh soaps, shampoos, or skin cleansers, hair coloring or permanent chemicals, hair removers or waxes, or skin products with alcohol, spices, astringents, or lime.
Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, stop using this medicine and call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to. Clindamycin and tretinoin topical can make you sunburn more easily. Apply sunscreen (SPF 30 or higher) every morning and throughout the day as needed. Avoid exposure to sunlight or tanning beds. Your skin may be more sensitive to weather extremes such as cold and wind. Protect your skin with clothing and use a moisturizing cream or lotion as needed.
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Stop using this medicine and call your doctor at once if you have:
severe redness, burning, stinging, or scaling of treated skin areas; or
diarrhea that is watery or bloody.
Common side effects may include:
mild skin irritation, dryness or peeling;
mild skin redness; or
itching of treated skin.
This is not a complete list of side effects and others may occur.
Store at room temperature away from moisture, heat, and light. Do not freeze.